Any examples of proteins/genes that preferentially express in the lateral or medial dorsal horn?


#1

Hi all,

I’m wondering if anyone can provide some examples of proteins or genes that express differentially in the lateral-medial axis, rather than dorsal-ventral. Normally, we see that genes express in a laminar way (lamina I/II vs. III-V, for example), and usually that expression is homogenous along the medial to dorsal axis.

But I’m looking at a protein that seems to show a lateral preference in some spinal neurons in the dorsal horn, and I’m wondering if there is precedent for that, and what it might mean.

Any examples in the literature or in your experience?