An excellent paper out implicating Piezo2 in human mechanosensation by looking at patients with nonsense mutations in this channel. This will surely be considered a landmark paper and demonstrates how we in the pain and sensory biology field can and should validate our findings in humans.
Chesler, A.T., Szczot, M., Bharucha-Goebel, D., Čeko, M., Donkervoort, S., Laubacher, C., Hayes, L.H., Alter, K., Zampieri, C., Stanley, C., et al. (2016). The Role of PIEZO2in Human Mechanosensation. N Engl J Med NEJMoa1602812.