# Journal Club
**URL:** https://forum.painresearcher.net/c/journal-club/5.md
[Latest](https://forum.painresearcher.net/latest.md) · [Categories](https://forum.painresearcher.net/categories.md) · [Tags](https://forum.painresearcher.net/tags.md)
---
## [About the Journal Club category](https://forum.painresearcher.net/t/about-the-journal-club-category/14)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0
Use this category to discuss papers and other published results.
---
## [Structure-guided design of a peripherally restricted chemogenetic system](https://forum.painresearcher.net/t/structure-guided-design-of-a-peripherally-restricted-chemogenetic-system/1328)
**Author:** [@vhms0706](https://forum.painresearcher.net/u/vhms0706)\
**Replies:** 3\
**Last updated:** [February 24, 2025, 12:15pm UTC](https://forum.painresearcher.net/t/structure-guided-design-of-a-peripherally-restricted-chemogenetic-system/1328 "2025-02-24T12:15:14Z")
Recent paper from Dr. Bryan Roth Lab on developing peripherally restricting DREADD system using receptor engineering: Structure-guided design of a peripherally restricted chemogenetic system - ScienceDirect I have a rea…
---
## [Establishing a Role for the Rostral Ventral Medulla in Morphine Analgesia](https://forum.painresearcher.net/t/establishing-a-role-for-the-rostral-ventral-medulla-in-morphine-analgesia/1311)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [November 8, 2024, 8:36pm UTC](https://forum.painresearcher.net/t/establishing-a-role-for-the-rostral-ventral-medulla-in-morphine-analgesia/1311 "2024-11-08T20:36:16Z")
A new study identifies key cells in an ensemble of morphine-responsive neurons within the RVM that promote mechanical antinociception. Tell us what you think of these results and how they might affect your research!
---
## [P2X receptors exhibit at least three modes of allosteric antagonism](https://forum.painresearcher.net/t/p2x-receptors-exhibit-at-least-three-modes-of-allosteric-antagonism/1298)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [October 11, 2024, 7:06pm UTC](https://forum.painresearcher.net/t/p2x-receptors-exhibit-at-least-three-modes-of-allosteric-antagonism/1298 "2024-10-11T19:06:33Z")
This paper establishes molecular determinants of allosteric antagonism, with three unique classes of antagonists that they call shallow, deep, and starfish. Read more and let us know what you think could come from this …
---
## [MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33](https://forum.painresearcher.net/t/mrgpra3-neurons-drive-cutaneous-immunity-against-helminths-through-selective-control-of-myeloid-derived-il-33/1295)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [October 4, 2024, 7:33pm UTC](https://forum.painresearcher.net/t/mrgpra3-neurons-drive-cutaneous-immunity-against-helminths-through-selective-control-of-myeloid-derived-il-33/1295 "2024-10-04T19:33:34Z")
Take a look at one of this week’s Editor’s Picks and let us know what you thought of the article below!
---
## [B cells drive neuropathic pain-related behaviors in mice through IgG-Fc gamma receptor signaling](https://forum.painresearcher.net/t/b-cells-drive-neuropathic-pain-related-behaviors-in-mice-through-igg-fc-gamma-receptor-signaling/1290)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [September 27, 2024, 8:40pm UTC](https://forum.painresearcher.net/t/b-cells-drive-neuropathic-pain-related-behaviors-in-mice-through-igg-fc-gamma-receptor-signaling/1290 "2024-09-27T20:40:48Z")
Check out one of this week’s Editor’s Picks and let us know what you think below!
---
## [Kappa opioids inhibit spinal output neurons to suppress itch](https://forum.painresearcher.net/t/kappa-opioids-inhibit-spinal-output-neurons-to-suppress-itch/1289)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [September 27, 2024, 8:36pm UTC](https://forum.painresearcher.net/t/kappa-opioids-inhibit-spinal-output-neurons-to-suppress-itch/1289 "2024-09-27T20:36:27Z")
Take a look at one of this week’s hand-selected Editor’s Picks and share your thoughts below!
---
## [Single-Point Mutations in Piezo2 Lead to Increased Mechanical Pain Sensitivity](https://forum.painresearcher.net/t/single-point-mutations-in-piezo2-lead-to-increased-mechanical-pain-sensitivity/1286)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [September 23, 2024, 4:49pm UTC](https://forum.painresearcher.net/t/single-point-mutations-in-piezo2-lead-to-increased-mechanical-pain-sensitivity/1286 "2024-09-23T16:49:45Z")
A new study reveals that removing the voltage-gated block on PIEZO2 channels leads to elevated and long-lasting nociceptor activity in response to mechanical stimulation. Do you agree with Sánchez-Carranza et al. that t…
---
## [HIF-2α-dependent induction of miR-29a restrains T1 activity during T cell dependent colitis](https://forum.painresearcher.net/t/hif-2-dependent-induction-of-mir-29a-restrains-t1-activity-during-t-cell-dependent-colitis/1283)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [September 20, 2024, 7:22pm UTC](https://forum.painresearcher.net/t/hif-2-dependent-induction-of-mir-29a-restrains-t1-activity-during-t-cell-dependent-colitis/1283 "2024-09-20T19:22:34Z")
https://www.iasp-pain.org/publications/pain-research-forum/papers-of-the-week/paper/hif-2%ce%b1-dependent-induction-of-mir-29a-restrains-t1-activity-during-t-cell-dependent-colitis/ Browse one of this week’s Papers of t…
---
## [A γδ T cell-IL-3 axis controls allergic responses through sensory neurons](https://forum.painresearcher.net/t/a-t-cell-il-3-axis-controls-allergic-responses-through-sensory-neurons/1279)
**Author:** [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Replies:** 0\
**Last updated:** [September 6, 2024, 8:11pm UTC](https://forum.painresearcher.net/t/a-t-cell-il-3-axis-controls-allergic-responses-through-sensory-neurons/1279 "2024-09-06T20:11:53Z")
https://www.iasp-pain.org/publications/pain-research-forum/papers-of-the-week/paper/a-γδ-t-cell-il-3-axis-controls-allergic-responses-through-sensory-neurons/ Take a look through one of this week’s Papers of the Week Ed…
---
## [Morphine-responsive neurons that regulate mechanical antinociception](https://forum.painresearcher.net/t/morphine-responsive-neurons-that-regulate-mechanical-antinociception/1268)
**Author:** [@RPSeal](https://forum.painresearcher.net/u/RPSeal)\
**Replies:** 0\
**Last updated:** [August 31, 2024, 9:22am UTC](https://forum.painresearcher.net/t/morphine-responsive-neurons-that-regulate-mechanical-antinociception/1268 "2024-08-31T09:22:45Z")
https://www.science.org/doi/10.1126/science.ado6593 Fatt et al, Science Vol 385, Issue 6712 (Aug 30, 2024) Patrik Ernfors’ Lab Editor’s summary It has been known for decades that a brainstem area called the rostral …
---
## [PRF Papers of the Week: Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain](https://forum.painresearcher.net/t/prf-papers-of-the-week-mast-cell-derived-bh4-and-serotonin-are-critical-mediators-of-postoperative-pain/1263)
**Author:** [@reneecphd](https://forum.painresearcher.net/u/reneecphd)\
**Replies:** 0\
**Last updated:** [August 30, 2024, 6:41pm UTC](https://forum.painresearcher.net/t/prf-papers-of-the-week-mast-cell-derived-bh4-and-serotonin-are-critical-mediators-of-postoperative-pain/1263 "2024-08-30T18:41:51Z")
Check out one of this week’s Papers of the Week Editor’s Picks and let us know what you think!
---
## [PRF Papers of the Week: Linking severe traumatic brain injury to pulmonary Infections: Translocation of intestinal bacteria mediated by nociceptor neurons](https://forum.painresearcher.net/t/prf-papers-of-the-week-linking-severe-traumatic-brain-injury-to-pulmonary-infections-translocation-of-intestinal-bacteria-mediated-by-nociceptor-neurons/1262)
**Author:** [@reneecphd](https://forum.painresearcher.net/u/reneecphd)\
**Replies:** 0\
**Last updated:** [August 30, 2024, 6:39pm UTC](https://forum.painresearcher.net/t/prf-papers-of-the-week-linking-severe-traumatic-brain-injury-to-pulmonary-infections-translocation-of-intestinal-bacteria-mediated-by-nociceptor-neurons/1262 "2024-08-30T18:39:24Z")
Check out one of this week’s Papers of the Week Editor’s Picks and let us know what you think!
---
## [Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis](https://forum.painresearcher.net/t/neuronal-substance-p-drives-metastasis-through-an-extracellular-rna-tlr7-axis/1240)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 16, 2024, 7:10pm UTC](https://forum.painresearcher.net/t/neuronal-substance-p-drives-metastasis-through-an-extracellular-rna-tlr7-axis/1240 "2024-08-16T19:10:40Z")
https://www.nature.com/articles/s41586-024-07767-5
---
## [Microglia-mediated degradation of perineuronal nets promotes pain](https://forum.painresearcher.net/t/microglia-mediated-degradation-of-perineuronal-nets-promotes-pain/988)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [May 26, 2022, 9:28pm UTC](https://forum.painresearcher.net/t/microglia-mediated-degradation-of-perineuronal-nets-promotes-pain/988 "2022-05-26T21:28:28Z")
https://www.science.org/doi/10.1126/science.abl6773 @ShanTan @jmogil
---
## [A novel spinal neuron connection for heat sensation](https://forum.painresearcher.net/t/a-novel-spinal-neuron-connection-for-heat-sensation/981)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [May 18, 2022, 10:07am UTC](https://forum.painresearcher.net/t/a-novel-spinal-neuron-connection-for-heat-sensation/981 "2022-05-18T10:07:36Z")
---
## [Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory](https://forum.painresearcher.net/t/lunatic-fringe-gfp-marks-lamina-specific-astrocytes-that-regulate-sensory/924)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [January 29, 2022, 3:58pm UTC](https://forum.painresearcher.net/t/lunatic-fringe-gfp-marks-lamina-specific-astrocytes-that-regulate-sensory/924 "2022-01-29T15:58:13Z")
https://www.jneurosci.org/content/42/4/567 @tberta
---
## [Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons](https://forum.painresearcher.net/t/single-nucleus-transcriptomic-analysis-of-human-dorsal-root-ganglion-neurons/909)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [November 26, 2021, 5:11pm UTC](https://forum.painresearcher.net/t/single-nucleus-transcriptomic-analysis-of-human-dorsal-root-ganglion-neurons/909 "2021-11-26T17:11:42Z")
Congrats to @stevedavidson and team on this landmark paper
---
## [Developing nociceptor-selective treatments for acute and chronic pain](https://forum.painresearcher.net/t/developing-nociceptor-selective-treatments-for-acute-and-chronic-pain/908)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [November 13, 2021, 4:04pm UTC](https://forum.painresearcher.net/t/developing-nociceptor-selective-treatments-for-acute-and-chronic-pain/908 "2021-11-13T16:04:06Z")
---
## [Scanned optogenetic control of mammalian somatosensory input to map](https://forum.painresearcher.net/t/scanned-optogenetic-control-of-mammalian-somatosensory-input-to-map/886)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [September 3, 2021, 6:13pm UTC](https://forum.painresearcher.net/t/scanned-optogenetic-control-of-mammalian-somatosensory-input-to-map/886 "2021-09-03T18:13:01Z")
---
## [Von Frey testing revisited: Provision of an online algorithm for improved accuracy of 50% thresholds](https://forum.painresearcher.net/t/von-frey-testing-revisited-provision-of-an-online-algorithm-for-improved-accuracy-of-50-thresholds/880)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 30, 2021, 10:34pm UTC](https://forum.painresearcher.net/t/von-frey-testing-revisited-provision-of-an-online-algorithm-for-improved-accuracy-of-50-thresholds/880 "2021-08-30T22:34:39Z")
https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1528 And webapp for calculation https://bioapps.shinyapps.io/von\_frey\_app/ @thicunha @tberta @ShanTan
---
## [Morphological and neurochemical characterization of glycinergic neurons in laminae I–IV of the mouse spinal dorsal horn](https://forum.painresearcher.net/t/morphological-and-neurochemical-characterization-of-glycinergic-neurons-in-laminae-i-iv-of-the-mouse-spinal-dorsal-horn/879)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 22, 2021, 2:36pm UTC](https://forum.painresearcher.net/t/morphological-and-neurochemical-characterization-of-glycinergic-neurons-in-laminae-i-iv-of-the-mouse-spinal-dorsal-horn/879 "2021-08-22T14:36:31Z")
https://onlinelibrary.wiley.com/doi/full/10.1002/cne.25232
---
## [Discrepancy in the Usage of GFAP as a Marker of Satellite Glial Cell Reactivity](https://forum.painresearcher.net/t/discrepancy-in-the-usage-of-gfap-as-a-marker-of-satellite-glial-cell-reactivity/878)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 22, 2021, 2:29pm UTC](https://forum.painresearcher.net/t/discrepancy-in-the-usage-of-gfap-as-a-marker-of-satellite-glial-cell-reactivity/878 "2021-08-22T14:29:54Z")
---
## [Passive transfer of fibromyalgia symptoms from patients to mice](https://forum.painresearcher.net/t/passive-transfer-of-fibromyalgia-symptoms-from-patients-to-mice/876)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 9, 2021, 2:56pm UTC](https://forum.painresearcher.net/t/passive-transfer-of-fibromyalgia-symptoms-from-patients-to-mice/876 "2021-08-09T14:56:35Z")
https://www.jci.org/articles/view/144201
---
## [Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions -](https://forum.painresearcher.net/t/sensory-neuron-derived-tafa4-promotes-macrophage-tissue-repair-functions/875)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 2, 2021, 1:14pm UTC](https://forum.painresearcher.net/t/sensory-neuron-derived-tafa4-promotes-macrophage-tissue-repair-functions/875 "2021-08-02T13:14:55Z")
---
## [Behavioral and nociceptor states of inflammatory pain across timescales in 2D and 3D](https://forum.painresearcher.net/t/behavioral-and-nociceptor-states-of-inflammatory-pain-across-timescales-in-2d-and-3d/851)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [June 17, 2021, 8:16pm UTC](https://forum.painresearcher.net/t/behavioral-and-nociceptor-states-of-inflammatory-pain-across-timescales-in-2d-and-3d/851 "2021-06-17T20:16:54Z")
---
## [Cage-lid hanging behavior as a translationally relevant... : PAIN](https://forum.painresearcher.net/t/cage-lid-hanging-behavior-as-a-translationally-relevant-pain/845)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 4\
**Last updated:** [June 5, 2021, 2:03pm UTC](https://forum.painresearcher.net/t/cage-lid-hanging-behavior-as-a-translationally-relevant-pain/845 "2021-06-05T14:03:44Z")
This looks very promising as a potentially high-throughput, minimally biased measure of spontaneous behavior for the assessment of pain. Bravo @Boninrp and @jmogil and team. Any guidance for the rest of us on setting…
---
## [Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury](https://forum.painresearcher.net/t/spinal-macrophages-resolve-nociceptive-hypersensitivity-after-peripheral-injury/811)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 1\
**Last updated:** [April 12, 2021, 1:16am UTC](https://forum.painresearcher.net/t/spinal-macrophages-resolve-nociceptive-hypersensitivity-after-peripheral-injury/811 "2021-04-12T01:16:50Z")
https://www.cell.com/neuron/fulltext/S0896-6273(21)00118-5 Exciting work from the Zylka lab
---
## [Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice](https://forum.painresearcher.net/t/long-lasting-analgesia-via-targeted-in-situ-repression-of-nav1-7-in-mice/819)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [March 13, 2021, 4:25am UTC](https://forum.painresearcher.net/t/long-lasting-analgesia-via-targeted-in-situ-repression-of-nav1-7-in-mice/819 "2021-03-13T04:25:07Z")
Nice work @mamocol and team
---
## [Use of Integrated Optical Clearing and 2-Photon Imaging to Investigate Sex](https://forum.painresearcher.net/t/use-of-integrated-optical-clearing-and-2-photon-imaging-to-investigate-sex/786)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [January 17, 2021, 10:48pm UTC](https://forum.painresearcher.net/t/use-of-integrated-optical-clearing-and-2-photon-imaging-to-investigate-sex/786 "2021-01-17T22:48:27Z")
[Next page](https://forum.painresearcher.net/c/journal-club/5.md?page=1)