# Journal Club
**URL:** https://forum.painresearcher.net/c/journal-club/5.md?page=1
[Latest](https://forum.painresearcher.net/latest.md) · [Categories](https://forum.painresearcher.net/categories.md) · [Tags](https://forum.painresearcher.net/tags.md)
**Page:** 2
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## [Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing](https://forum.painresearcher.net/t/single-cell-sequencing-reveals-glial-specific-responses-to-tissue-processing/780)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [December 4, 2020, 3:06pm UTC](https://forum.painresearcher.net/t/single-cell-sequencing-reveals-glial-specific-responses-to-tissue-processing/780 "2020-12-04T15:06:34Z")
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## [Parallel ascending spinal pathways for affective touch and pain](https://forum.painresearcher.net/t/parallel-ascending-spinal-pathways-for-affective-touch-and-pain/776)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [November 15, 2020, 9:13pm UTC](https://forum.painresearcher.net/t/parallel-ascending-spinal-pathways-for-affective-touch-and-pain/776 "2020-11-15T21:13:27Z")
https://www.nature.com/articles/s41586-020-2860-1
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## [Decoding Cellular Mechanisms for Mechanosensory Discrimination](https://forum.painresearcher.net/t/decoding-cellular-mechanisms-for-mechanosensory-discrimination/773)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [November 14, 2020, 1:58pm UTC](https://forum.painresearcher.net/t/decoding-cellular-mechanisms-for-mechanosensory-discrimination/773 "2020-11-14T13:58:23Z")
https://www.cell.com/neuron/fulltext/S0896-6273(20)30852-7
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## [A Functional Topographic Map for Spinal Sensorimotor Reflexes](https://forum.painresearcher.net/t/a-functional-topographic-map-for-spinal-sensorimotor-reflexes/772)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [November 14, 2020, 1:57pm UTC](https://forum.painresearcher.net/t/a-functional-topographic-map-for-spinal-sensorimotor-reflexes/772 "2020-11-14T13:57:57Z")
https://www.cell.com/neuron/fulltext/S0896-6273(20)30771-6
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## [SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes](https://forum.painresearcher.net/t/sumoylation-of-enzymes-and-ion-channels-in-sensory-neurons-protects-against-metabolic-dysfunction-neuropathy-and-sensory-loss-in-diabetes/736)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 3, 2020, 8:41pm UTC](https://forum.painresearcher.net/t/sumoylation-of-enzymes-and-ion-channels-in-sensory-neurons-protects-against-metabolic-dysfunction-neuropathy-and-sensory-loss-in-diabetes/736 "2020-08-03T20:41:50Z")
https://www.cell.com/neuron/fulltext/S0896-6273(20)30491-8
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## [Chronic pain produces hypervigilance to predator odor in mice](https://forum.painresearcher.net/t/chronic-pain-produces-hypervigilance-to-predator-odor-in-mice/735)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 3, 2020, 7:50pm UTC](https://forum.painresearcher.net/t/chronic-pain-produces-hypervigilance-to-predator-odor-in-mice/735 "2020-08-03T19:50:19Z")
https://www.cell.com/current-biology/fulltext/S0960-9822(20)30841-1
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## [Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve](https://forum.painresearcher.net/t/behavioral-biochemical-and-electrophysiological-changes-in-spared-nerve/727)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [May 21, 2020, 12:53pm UTC](https://forum.painresearcher.net/t/behavioral-biochemical-and-electrophysiological-changes-in-spared-nerve/727 "2020-05-21T12:53:27Z")
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## [The ARRIVE guidelines 2019: updated guidelines for reporting animal research](https://forum.painresearcher.net/t/the-arrive-guidelines-2019-updated-guidelines-for-reporting-animal-research/720)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 7\
**Last updated:** [March 22, 2020, 7:03pm UTC](https://forum.painresearcher.net/t/the-arrive-guidelines-2019-updated-guidelines-for-reporting-animal-research/720 "2020-03-22T19:03:20Z")
Highly recommended read for everyone doing animal research These should be the standards we hold ourselves to And we’d save ourselves a lot of trouble if our planning and experiments started by looking at these checkli…
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## [Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map](https://forum.painresearcher.net/t/astrocyte-layers-in-the-mammalian-cerebral-cortex-revealed-by-a-single-cell-in-situ-transcriptomic-map/718)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [March 16, 2020, 11:21pm UTC](https://forum.painresearcher.net/t/astrocyte-layers-in-the-mammalian-cerebral-cortex-revealed-by-a-single-cell-in-situ-transcriptomic-map/718 "2020-03-16T23:21:47Z")
https://www.nature.com/articles/s41593-020-0602-1
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## [Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and](https://forum.painresearcher.net/t/mycobacterium-tuberculosis-sulfolipid-1-activates-nociceptive-neurons-and/710)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [March 7, 2020, 1:51pm UTC](https://forum.painresearcher.net/t/mycobacterium-tuberculosis-sulfolipid-1-activates-nociceptive-neurons-and/710 "2020-03-07T13:51:19Z")
Yet another excellent demonstration that sensory neurons have many more roles than we expected. Great paper, with @Theodore.price lab making key contributions.
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## [Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and](https://forum.painresearcher.net/t/tmem119-egfp-and-tmem119-creert2-transgenic-mice-for-labeling-and/597)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 16\
**Last updated:** [February 26, 2020, 9:52pm UTC](https://forum.painresearcher.net/t/tmem119-egfp-and-tmem119-creert2-transgenic-mice-for-labeling-and/597 "2020-02-26T21:52:42Z")
@ShanTan you might find this useful
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## [TACAN Is an Ion Channel Involved in Sensing Mechanical Pain: Cell](https://forum.painresearcher.net/t/tacan-is-an-ion-channel-involved-in-sensing-mechanical-pain-cell/699)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 2\
**Last updated:** [February 21, 2020, 8:36pm UTC](https://forum.painresearcher.net/t/tacan-is-an-ion-channel-involved-in-sensing-mechanical-pain-cell/699 "2020-02-21T20:36:47Z")
https://www.cell.com/cell/fulltext/S0092-8674(20)30114-8?rss=yes
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## [A machine-vision approach for automated pain measurement at millisecond](https://forum.painresearcher.net/t/a-machine-vision-approach-for-automated-pain-measurement-at-millisecond/700)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [February 20, 2020, 11:07pm UTC](https://forum.painresearcher.net/t/a-machine-vision-approach-for-automated-pain-measurement-at-millisecond/700 "2020-02-20T23:07:42Z")
Exciting work from Abdus-Saboor lab with great collab from @gcorder @ShanTan @tberta @runDRG @esypek @CandlerPaige
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## [Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating](https://forum.painresearcher.net/t/intra-articular-aav-php-s-mediated-chemogenetic-targeting-of-knee-innervating/696)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [February 9, 2020, 4:11pm UTC](https://forum.painresearcher.net/t/intra-articular-aav-php-s-mediated-chemogenetic-targeting-of-knee-innervating/696 "2020-02-09T16:11:11Z")
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## [Hello Everyone,](https://forum.painresearcher.net/t/hello-everyone/693)
**Author:** [@SheritaHebert](https://forum.painresearcher.net/u/SheritaHebert)\
**Replies:** 0\
**Last updated:** [January 22, 2020, 5:05am UTC](https://forum.painresearcher.net/t/hello-everyone/693 "2020-01-22T05:05:24Z")
Hello Everyone, I’m Sherita J Hebert and new in this forum.
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## [Sensory Neurons Innervate Peripheral Lymph Nodes and Locally Regulate Gene](https://forum.painresearcher.net/t/sensory-neurons-innervate-peripheral-lymph-nodes-and-locally-regulate-gene/673)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 1\
**Last updated:** [December 2, 2019, 4:46pm UTC](https://forum.painresearcher.net/t/sensory-neurons-innervate-peripheral-lymph-nodes-and-locally-regulate-gene/673 "2019-12-02T16:46:26Z")
@tberta @thicunha
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## [Transcriptional reprogramming of distinct peripheral sensory neuron subtypes](https://forum.painresearcher.net/t/transcriptional-reprogramming-of-distinct-peripheral-sensory-neuron-subtypes/674)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 1\
**Last updated:** [December 2, 2019, 3:10pm UTC](https://forum.painresearcher.net/t/transcriptional-reprogramming-of-distinct-peripheral-sensory-neuron-subtypes/674 "2019-12-02T15:10:57Z")
This is going to be a landmark paper. Answers longstanding questions about nerve injury with an intriguing finding. The neurons all take on an ‘injured’ phenotype. How do they remember their identities from before? The…
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## [A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the](https://forum.painresearcher.net/t/a-novel-tmem119-tdtomato-reporter-mouse-model-for-studying-microglia-in-the/665)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [October 13, 2019, 2:37pm UTC](https://forum.painresearcher.net/t/a-novel-tmem119-tdtomato-reporter-mouse-model-for-studying-microglia-in-the/665 "2019-10-13T14:37:45Z")
@shantan @tberta
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## [Development of a Mouse Pain Scale Using Sub-second Behavioral Mapping and Statistical Modeling](https://forum.painresearcher.net/t/development-of-a-mouse-pain-scale-using-sub-second-behavioral-mapping-and-statistical-modeling/664)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [September 29, 2019, 1:45pm UTC](https://forum.painresearcher.net/t/development-of-a-mouse-pain-scale-using-sub-second-behavioral-mapping-and-statistical-modeling/664 "2019-09-29T13:45:39Z")
Important new paper from Abdus-Saboor et a. describing the use of high speed video to analyze subtle features of paw withdrawal that distinguish pain-like vs. non-pain-like behaviors. https://www.cell.com/cell-reports/f…
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## [Structure and mechanogating of the mammalian tactile channel PIEZO2](https://forum.painresearcher.net/t/structure-and-mechanogating-of-the-mammalian-tactile-channel-piezo2/647)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 22, 2019, 12:32am UTC](https://forum.painresearcher.net/t/structure-and-mechanogating-of-the-mammalian-tactile-channel-piezo2/647 "2019-08-22T00:32:08Z")
https://www.nature.com/articles/s41586-019-1505-8
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## [Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia](https://forum.painresearcher.net/t/defining-a-spinal-microcircuit-that-gates-myelinated-afferent-input-implications-for-tactile-allodynia/637)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 1\
**Last updated:** [August 7, 2019, 2:14pm UTC](https://forum.painresearcher.net/t/defining-a-spinal-microcircuit-that-gates-myelinated-afferent-input-implications-for-tactile-allodynia/637 "2019-08-07T14:14:12Z")
Great work from @MGradwell and colleagues
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## [Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch](https://forum.painresearcher.net/t/identification-of-a-spinal-circuit-for-mechanical-and-persistent-spontaneous-itch/639)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 7, 2019, 10:14am UTC](https://forum.painresearcher.net/t/identification-of-a-spinal-circuit-for-mechanical-and-persistent-spontaneous-itch/639 "2019-08-07T10:14:05Z")
New work out of Bo Duan’s lab. @tberta: Look at the TLR5 neurons!
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## [Neuronal diversity in the somatosensory system: bridging the gap between cell type and function](https://forum.painresearcher.net/t/neuronal-diversity-in-the-somatosensory-system-bridging-the-gap-between-cell-type-and-function/638)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 7, 2019, 10:12am UTC](https://forum.painresearcher.net/t/neuronal-diversity-in-the-somatosensory-system-bridging-the-gap-between-cell-type-and-function/638 "2019-08-07T10:12:53Z")
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## [Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila](https://forum.painresearcher.net/t/nerve-injury-drives-a-heightened-state-of-vigilance-and-neuropathic-sensitization-in-drosophila/636)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [August 7, 2019, 10:10am UTC](https://forum.painresearcher.net/t/nerve-injury-drives-a-heightened-state-of-vigilance-and-neuropathic-sensitization-in-drosophila/636 "2019-08-07T10:10:32Z")
Nerve injury in Drosophila
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## [ezTrack: An open-source video analysis pipeline for the investigation of](https://forum.painresearcher.net/t/eztrack-an-open-source-video-analysis-pipeline-for-the-investigation-of/596)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [April 30, 2019, 2:46am UTC](https://forum.painresearcher.net/t/eztrack-an-open-source-video-analysis-pipeline-for-the-investigation-of/596 "2019-04-30T02:46:59Z")
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## [A proposal for validation of antibodies - Nature Methods](https://forum.painresearcher.net/t/a-proposal-for-validation-of-antibodies-nature-methods/589)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [April 13, 2019, 1:02am UTC](https://forum.painresearcher.net/t/a-proposal-for-validation-of-antibodies-nature-methods/589 "2019-04-13T01:02:07Z")
https://www.nature.com/articles/nmeth.3995 These are solid, specific recommendations for how to validate antibodies. We should all heed these, IMO, even if it takes a while.
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## [Distinct transcriptional responses of mouse sensory neurons in models of](https://forum.painresearcher.net/t/distinct-transcriptional-responses-of-mouse-sensory-neurons-in-models-of/587)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [April 8, 2019, 2:43am UTC](https://forum.painresearcher.net/t/distinct-transcriptional-responses-of-mouse-sensory-neurons-in-models-of/587 "2019-04-08T02:43:33Z")
@tberta - I’ve been waiting for something like this. Just wish it had been RNA-seq.
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## [Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis](https://forum.painresearcher.net/t/spatiotemporal-dynamics-of-molecular-pathology-in-amyotrophic-lateral-sclerosis/586)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [April 5, 2019, 6:10pm UTC](https://forum.painresearcher.net/t/spatiotemporal-dynamics-of-molecular-pathology-in-amyotrophic-lateral-sclerosis/586 "2019-04-05T18:10:03Z")
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## [Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch](https://forum.painresearcher.net/t/dorsal-horn-gastrin-releasing-peptide-expressing-neurons-transmit-spinal-itch/575)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 3\
**Last updated:** [March 21, 2019, 3:37pm UTC](https://forum.painresearcher.net/t/dorsal-horn-gastrin-releasing-peptide-expressing-neurons-transmit-spinal-itch/575 "2019-03-21T15:37:24Z")
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## [Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior](https://forum.painresearcher.net/t/distinct-modes-of-presynaptic-inhibition-of-cutaneous-afferents-and-their-functions-in-behavior/569)
**Author:** [@achamess](https://forum.painresearcher.net/u/achamess)\
**Replies:** 0\
**Last updated:** [February 28, 2019, 2:34pm UTC](https://forum.painresearcher.net/t/distinct-modes-of-presynaptic-inhibition-of-cutaneous-afferents-and-their-functions-in-behavior/569 "2019-02-28T14:34:59Z")
https://www.cell.com/neuron/fulltext/S0896-6273(19)30111-4
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