# Advillin-ChR2 -\> Failure to thrive?

**URL:** <https://forum.painresearcher.net/t/advillin-chr2-failure-to-thrive/328>\
**Category:** Animal Behavior and Models\
**Created:** [November 16, 2017, 9:18pm UTC](https://forum.painresearcher.net/t/advillin-chr2-failure-to-thrive/328 "2017-11-16T21:18:00Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![achamess](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/achamess/32/534_2.png) [@achamess](https://forum.painresearcher.net/u/achamess)\
**Post date:** [November 16, 2017, 9:18pm UTC](https://forum.painresearcher.net/t/advillin-chr2-failure-to-thrive/328/1 "2017-11-16T21:18:00Z")

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Hey all,  
We’ve been breeding some Advillin-ChR2 mice by cross Advillin-Cre x Ai32. Multiple litters from different parents have been small and sickly, with many of them dying. It seems to be genotype specific, since the Cre(-) littermates are normal. Anyone seen this before?