# Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

**URL:** <https://forum.painresearcher.net/t/chemogenetics-revealed-dreadd-occupancy-and-activation-via-converted-clozapine/242>\
**Category:** Journal Club\
**Tags:** chemogenetics\
**Created:** [August 3, 2017, 8:29pm UTC](https://forum.painresearcher.net/t/chemogenetics-revealed-dreadd-occupancy-and-activation-via-converted-clozapine/242 "2017-08-03T20:29:43Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![achamess](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/achamess/32/534_2.png) [@achamess](https://forum.painresearcher.net/u/achamess)\
**Post date:** [August 3, 2017, 8:29pm UTC](https://forum.painresearcher.net/t/chemogenetics-revealed-dreadd-occupancy-and-activation-via-converted-clozapine/242/1 "2017-08-03T20:29:43Z")

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> **[Chemogenetics revealed: DREADD occupancy and activation via converted clozapine](https://science.sciencemag.org/content/357/6350/503.full)**
>
> Designer receptors exclusively activated by designer drugs (DREADDs) constitute a powerful chemogenetic strategy that can modulate nerve cell activity in freely moving animal preparations. Gomez et al. used radioligand receptor occupancy measurements...

Further reason to make sure we’re designing our experiments carefully using these powerful tools