# Comprehensive study of AAVs for Spinal Cord and DRG
**URL:** https://forum.painresearcher.net/t/comprehensive-study-of-aavs-for-spinal-cord-and-drg/227
**Category:** Journal Club
**Created:** [July 18, 2017, 6:00pm UTC](https://forum.painresearcher.net/t/comprehensive-study-of-aavs-for-spinal-cord-and-drg/227 "2017-07-18T18:00:02Z")
**Posts on this page:** 2
**Page:** 1
### Author:  [@achamess](https://forum.painresearcher.net/u/achamess)
#### Post date: [July 18, 2017, 6:00pm UTC](https://forum.painresearcher.net/t/comprehensive-study-of-aavs-for-spinal-cord-and-drg/227/1 "2017-07-18T18:00:02Z")
> **[Spinal nociceptive circuit analysis with recombinant adeno‐associated...](https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.14124)**
>
> rAAVs are powerful tools to manipulate neuronal circuits. We have compared different serotypes and promoters to either restrict transduction to local neurons of the spinal dorsal horn or to maximize ...
Very useful info here.
@tberta @RPSeal @jordangmccall @liz @thicunha@zhzhj131421 @SamineniV
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### Author:  [@RPSeal](https://forum.painresearcher.net/u/RPSeal)
#### Post date: [July 31, 2017, 2:51am UTC](https://forum.painresearcher.net/t/comprehensive-study-of-aavs-for-spinal-cord-and-drg/227/2 "2017-07-31T02:51:03Z")
Great paper. Thanks for pointing it out. I recently visited Uli, Hendrik and colleagues. They showed me these data. Striking is the effect of the hSyn promoter in DRG. Great if you want to avoid but according to this study, perhaps not great if you want to hit them. Could have been one of the keys to our success in avoiding DRG expression in our Neuron 2015 paper. Interested to see what others have found with this promoter, which I think is terrific for expression in spinal cord neurons.