# Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers

**URL:** <https://forum.painresearcher.net/t/distinct-behavioral-responses-evoked-by-selective-optogenetic-stimulation-of-the-major-trpv1-and-mrgd-subsets-of-c-fibers/348>\
**Category:** Journal Club\
**Created:** [December 1, 2017, 6:44pm UTC](https://forum.painresearcher.net/t/distinct-behavioral-responses-evoked-by-selective-optogenetic-stimulation-of-the-major-trpv1-and-mrgd-subsets-of-c-fibers/348 "2017-12-01T18:44:21Z")\
**Posts on this page:** 1\
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**Author:** ![achamess](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/achamess/32/534_2.png) [@achamess](https://forum.painresearcher.net/u/achamess)\
**Post date:** [December 1, 2017, 6:44pm UTC](https://forum.painresearcher.net/t/distinct-behavioral-responses-evoked-by-selective-optogenetic-stimulation-of-the-major-trpv1-and-mrgd-subsets-of-c-fibers/348/1 "2017-12-01T18:44:21Z")

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> **[Distinct behavioral responses evoked by selective... : PAIN](https://journals.lww.com/pain/Abstract/2017/12000/Distinct_behavioral_responses_evoked_by_selective.8.aspx)**
>
> nts. TRPV1+ and MrgD+ fibers have been reported to be primarily involved in thermal and mechanical nociception, respectively. Yet, their functional assessment in somatosensory transmission relied on ablation strategies that do not account for...

Distinct behavioral responses evoked by selective… : PAIN

And interesting commentary:

> **[Shedding light on the contribution of different c-fibre... : PAIN](https://journals.lww.com/pain/Citation/2017/12000/Shedding_light_on_the_contribution_of_different.2.aspx)**
>
> An abstract is unavailable.

Lesson: We should be cautious about how we interpret paw withdrawal. And not all nociceptors lead to the same affective experiences.