# In vivo dynamics of AAV-mediated gene delivery to sensory neurons of the **URL:** \ **Category:** Journal Club\ **Created:** [November 16, 2017, 6:54pm UTC](https://forum.painresearcher.net/t/in-vivo-dynamics-of-aav-mediated-gene-delivery-to-sensory-neurons-of-the/327 "2017-11-16T18:54:49Z")\ **Posts on this page:** 1\ **Showing post:** 2
**Author:** ![achamess](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/achamess/32/534_2.png) [@achamess](https://forum.painresearcher.net/u/achamess)\ **Post date:** [November 16, 2017, 6:55pm UTC](https://forum.painresearcher.net/t/in-vivo-dynamics-of-aav-mediated-gene-delivery-to-sensory-neurons-of-the/327/2 "2017-11-16T18:55:37Z")
This is useful and pretty rigorous. Looks like AAV1 is best from the TG. That jives well with what I found recently from the paw, although I still need to quantify. > [@Stuff I tried during grad school/post-doc that won't get published but could be useful](http://forum.painresearcher.net/t/stuff-i-tried-during-grad-school-post-doc-that-wont-get-published-but-could-be-useful/302/17): > > AAV1-hSyn-Cre retrogradely infects DRG neurons from the paw. Mouse: Ai32 (R26-CAG-LSL-ChR2) Titer: ~1E13 -\> 10 ul injected To be determined: Percentage of neurons infected Does it jump to spinal neurons [anterogradely](http://www.cell.com/neuron/pdf/S0896-6273(16)30913-8.pdf) This behavior is 3 weeks post infection. At 1 week, there was no behavior. Also, at same time period, retro-AAV-Cre injected into the same mouse line did not produce any behavior. So, I’m not optimistic about retro-AAV for mouse paw. @tberta @YongHo --- _[View the full topic](https://forum.painresearcher.net/t/in-vivo-dynamics-of-aav-mediated-gene-delivery-to-sensory-neurons-of-the/327)._