# P2X receptors exhibit at least three modes of allosteric antagonism

**URL:** <https://forum.painresearcher.net/t/p2x-receptors-exhibit-at-least-three-modes-of-allosteric-antagonism/1298>\
**Category:** Journal Club\
**Created:** [October 11, 2024, 7:06pm UTC](https://forum.painresearcher.net/t/p2x-receptors-exhibit-at-least-three-modes-of-allosteric-antagonism/1298 "2024-10-11T19:06:33Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![PRF-Editorial-Board](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/prf-editorial-board/32/552_2.png) [@PRF-Editorial-Board](https://forum.painresearcher.net/u/PRF-Editorial-Board)\
**Post date:** [October 11, 2024, 7:06pm UTC](https://forum.painresearcher.net/t/p2x-receptors-exhibit-at-least-three-modes-of-allosteric-antagonism/1298/1 "2024-10-11T19:06:33Z")

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This paper establishes molecular determinants of allosteric antagonism, with three unique classes of antagonists that they call _shallow_, _deep_, and _starfish_. Read more and let us know what you think could come from this potential new pharmacological target!

> **[P2X receptors exhibit at least three modes of allosteric antagonism. -...](https://www.iasp-pain.org/publications/pain-research-forum/papers-of-the-week/paper/p2x-receptors-exhibit-at-least-three-modes-of-allosteric-antagonism/)**
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> P2X receptors are trimeric ion channels activated by adenosine triphosphate (ATP) that contribute to pathophysiological processes ranging from asthma to neuropathic pain and neurodegeneration. A number of small-molecule antagonists have \[…\]