# Paper: Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

**URL:** <https://forum.painresearcher.net/t/paper-coupled-activation-of-primary-sensory-neurons-contributes-to-chronic-pain/96>\
**Category:** Journal Club\
**Created:** [September 2, 2016, 9:32pm UTC](https://forum.painresearcher.net/t/paper-coupled-activation-of-primary-sensory-neurons-contributes-to-chronic-pain/96 "2016-09-02T21:32:15Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![achamess](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/achamess/32/534_2.png) [@achamess](https://forum.painresearcher.net/u/achamess)\
**Post date:** [September 2, 2016, 9:32pm UTC](https://forum.painresearcher.net/t/paper-coupled-activation-of-primary-sensory-neurons-contributes-to-chronic-pain/96/1 "2016-09-02T21:32:15Z")

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This is a fascinating paper using _in vivo_ DRG calcium imaging to interrogate the ensemble activity of DRG neurons in naive and pathological conditions. This is an exemplar of what emerging and powerful techniques such as two-photon calcium imaging can offer. The functional coupling of DRG neurons to each other via SGCs opens many new questions and offers a new avenue for therapeutics.

**Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain**  
[http://www.cell.com/neuron/fulltext/S0896-6273(16)30460-3](http://www.cell.com/neuron/fulltext/S0896-6273(16)30460-3)