# PRF Papers of the Week: Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain

**URL:** <https://forum.painresearcher.net/t/prf-papers-of-the-week-mast-cell-derived-bh4-and-serotonin-are-critical-mediators-of-postoperative-pain/1263>\
**Category:** Journal Club\
**Created:** [August 30, 2024, 6:41pm UTC](https://forum.painresearcher.net/t/prf-papers-of-the-week-mast-cell-derived-bh4-and-serotonin-are-critical-mediators-of-postoperative-pain/1263 "2024-08-30T18:41:51Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![reneecphd](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/reneecphd/32/546_2.png) [@reneecphd](https://forum.painresearcher.net/u/reneecphd)\
**Post date:** [August 30, 2024, 6:41pm UTC](https://forum.painresearcher.net/t/prf-papers-of-the-week-mast-cell-derived-bh4-and-serotonin-are-critical-mediators-of-postoperative-pain/1263/1 "2024-08-30T18:41:51Z")

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> **[Mast cell-derived BH4 and serotonin are critical mediators of postoperative...](https://www.iasp-pain.org/publications/pain-research-forum/papers-of-the-week/paper/mast-cell-derived-bh4-and-serotonin-are-critical-mediators-of-postoperative-pain/)**
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> Postoperative pain affects most patients after major surgery and can transition to chronic pain. The considerable side effects and limited efficacy of current treatments underline the need for new therapeutic \[…\]

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