# Transcriptional reprogramming of distinct peripheral sensory neuron subtypes

**URL:** <https://forum.painresearcher.net/t/transcriptional-reprogramming-of-distinct-peripheral-sensory-neuron-subtypes/674>\
**Category:** Journal Club\
**Created:** [December 1, 2019, 3:22am UTC](https://forum.painresearcher.net/t/transcriptional-reprogramming-of-distinct-peripheral-sensory-neuron-subtypes/674 "2019-12-01T03:22:22Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![achamess](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/achamess/32/534_2.png) [@achamess](https://forum.painresearcher.net/u/achamess)\
**Post date:** [December 1, 2019, 3:22am UTC](https://forum.painresearcher.net/t/transcriptional-reprogramming-of-distinct-peripheral-sensory-neuron-subtypes/674/1 "2019-12-01T03:22:22Z")

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> **[Transcriptional reprogramming of distinct peripheral sensory neuron subtypes...](https://www.biorxiv.org/content/10.1101/838854v1)**
>
> Primary somatosensory neurons are specialized to transmit specific types of sensory information through differences in cell size, myelination, and the expression of distinct receptors and ion channels, which together define their transcriptional and...

This is going to be a landmark paper. Answers longstanding questions about nerve injury with an intriguing finding. The neurons all take on an ‘injured’ phenotype. How do they remember their identities from before? There must be some internal factors in the cells that allow them to resume their identities during recovery. Many new questions opened up by this study.

Also, very similar findings from a contemporaneous study:

> **[Stereotyped transcriptomic transformation of somatosensory neurons in...](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783272/)**
>
> In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces upregulation of many genes in somatosensory neurons. Here we used single cell transcriptomics to probe the effects of partial infraorbital transection of the...

It’s fantastic to see convergent evidence from two groups using similar approaches.

@tberta @thicunha @Theodore.price

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**Author:** ![thicunha](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/thicunha/32/386_2.png) [@thicunha](https://forum.painresearcher.net/u/thicunha)\
**Post date:** [December 2, 2019, 3:10pm UTC](https://forum.painresearcher.net/t/transcriptional-reprogramming-of-distinct-peripheral-sensory-neuron-subtypes/674/2 "2019-12-02T15:10:57Z")

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Nice papers and resources !!