# Which mouse model most consistently produces pain-like hypersensitivity in your hands? **URL:** \ **Category:** Experimental Techniques\ **Created:** [September 7, 2019, 11:12am UTC](https://forum.painresearcher.net/t/which-mouse-model-most-consistently-produces-pain-like-hypersensitivity-in-your-hands/655 "2019-09-07T11:12:56Z")\ **Posts on this page:** 1\ **Showing post:** 5
**Author:** ![achamess](https://yyz2.discourse-cdn.com/flex030/user_avatar/forum.painresearcher.net/achamess/32/534_2.png) [@achamess](https://forum.painresearcher.net/u/achamess)\ **Post date:** [September 10, 2019, 12:24am UTC](https://forum.painresearcher.net/t/which-mouse-model-most-consistently-produces-pain-like-hypersensitivity-in-your-hands/655/5 "2019-09-10T00:24:42Z")
What kinds of troubles with CFA? Like this? > [@Mechanical threshold testing after CFA in hindpaw -\> Edema in mid hindpaw makes the mice less sensitive?](https://forum.painresearcher.net/t/mechanical-threshold-testing-after-cfa-in-hindpaw-edema-in-mid-hindpaw-makes-the-mice-less-sensitive/122): > > Hi all, So I’m working with the CFA inflammatory model in the hindpaw. I inject 20 ul of CFA subcutaneously. By 24 hours, the hindpaw is very edematous and much larger than the contralateral. I’ve noticed though that when I test von Frey on the mid hindpaw, where it is most swollen, the mice are actually pretty insensitive, which is not what I expect. They seem most sensitive very anteriorly, just behind the toes. Have you noticed this? @ram_kandasamy @LegakisL @tberta @jmogil @fmoehring @thi… --- _[View the full topic](https://forum.painresearcher.net/t/which-mouse-model-most-consistently-produces-pain-like-hypersensitivity-in-your-hands/655)._