Paper: The Role of PIEZO2 in Human Mechanosensation


An excellent paper out implicating Piezo2 in human mechanosensation by looking at patients with nonsense mutations in this channel. This will surely be considered a landmark paper and demonstrates how we in the pain and sensory biology field can and should validate our findings in humans.

Chesler, A.T., Szczot, M., Bharucha-Goebel, D., Čeko, M., Donkervoort, S., Laubacher, C., Hayes, L.H., Alter, K., Zampieri, C., Stanley, C., et al. (2016). The Role of PIEZO2in Human Mechanosensation. N Engl J Med NEJMoa1602812.