Is there literature/can someone explain to me why we don’t see thermal hypersensitivity after SNI, but we see mechanical? Never understood why we wouldn’t see both. Thanks!
Well by thermal do you mean any temperature, or just warm/hot?
They do have cold hypersensitivity
If you’re asking why not hypersensitivity to warming/heating, probably because whatever neuronal population or mechanism is responsible for that attribute is not induced in SNI. Perhaps others will have a better explanation @thicunha
The diference in neuronal population is one possible explanation, but why cold responsive neurons are but not heat encoding neurons are not sensitized is not clear. I also believe that SNI hypersensitivity (ate least in the Sural innervating region) is mainly due to central processes (spinal cord mechanisms/ maybe DRGs mechanism), whereas thermal hypersensitivity is normally a peripheral mechanism. @tberta @jmogil