So I'm working with the CFA inflammatory model in the hindpaw. I inject 20 ul of CFA subcutaneously. By 24 hours, the hindpaw is very edematous and much larger than the contralateral. I've noticed though that when I test von Frey on the mid hindpaw, where it is most swollen, the mice are actually pretty insensitive, which is not what I expect. They seem most sensitive very anteriorly, just behind the toes.
Have you noticed this?
@ram_kandasamy @LegakisL @tberta @jmogil @fmoehring @thicunha