In your hands, which mouse model of pain most reliably and strongly produces hypersensitivity in nociceptive assays for you? You can specify which assays in the replies below.
Not all models work for all researchers at all places.
For me, if I had to pick one of these, I would say SNI produces the most consistent, reproducible and strong hypersensitivity. Most all animals are very sensitive and the surgery is pretty easy to do correctly.
And which doesn’t? Which of these models hasn’t produced the expected results? For me, CFA and Chemotherapy have been lackluster.
- Complete Freund’s Adjuvant (CFA)
- Paclitaxel Chemotherapy
- Spared Nerve Injury
- Chronic Constriction Injury
- Plantar Incision
- Capsaicin (2º hyperalgesia)
- Formalin (2º hyperalgesia)
- Other (reply below)