Which mouse model most consistently produces pain-like hypersensitivity in your hands?

[achamess]

What kinds of troubles with CFA?

Like this?

Mechanical threshold testing after CFA in hindpaw -> Edema in mid hindpaw makes the mice less sensitive?

Hi all, So I’m working with the CFA inflammatory model in the hindpaw. I inject 20 ul of CFA subcutaneously. By 24 hours, the hindpaw is very edematous and much larger than the contralateral. I’ve noticed though that when I test von Frey on the mid hindpaw, where it is most swollen, the mice are actually pretty insensitive, which is not what I expect. They seem most sensitive very anteriorly, just behind the toes. Have you noticed this? @ram_kandasamy @LegakisL @tberta @jmogil @fmoehring @thi…