Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

achamess · August 7, 2019, 10:12am

ncbi.nlm.nih.gov

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia.

KA Boyle, MA Gradwell, T Yasaka, AC Dickie, E Polgár, RP Ganley, DPH Orr, M Watanabe, VE Abraira, ED Kuehn, AL Zimmerman, DD Ginty, RJ Callister, BA Graham and DI Hughes, Cell reports, Jul 2019 09

Chronic pain presents a major unmet clinical problem. The development of more effective treatments is hindered by our limited understanding of the neuronal circuits underlying sensory perception. Here, we show that parvalbumin (PV)-expressing dorsal horn interneurons modulate the passage of sensory information conveyed by low-threshold mechanoreceptors (LTMRs) directly via presynaptic inhibition and also gate the polysynaptic relay of LTMR input to pain circuits by inhibiting lamina II excitatory interneurons whose axons project into lamina I. We show changes in the functional properties of these PV interneurons following peripheral nerve injury and that silencing these cells unmasks a circuit that allows innocuous touch inputs to activate pain circuits by increasing network activity in laminae I-IV. Such changes are likely to result in the development of tactile allodynia and could be targeted for more effective treatment of mechanical pain.

Great work from @MGradwell and colleagues

MGradwell · August 7, 2019, 2:14pm

Thanks Alex! Glad you liked it

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Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

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