Spinal Circuits for Touch, Pain, and Itch

achamess · October 10, 2017, 12:41am

ncbi.nlm.nih.gov

Spinal Circuits for Touch, Pain, and Itch.

SC Koch, D Acton and M Goulding, Annual review of physiology, Sep 27 2017

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors and for the dynamic control of movement in response to external stimuli. This review outlines recent efforts using genetic approaches in the mouse to map the spinal cord circuits that transmit and gate the cutaneous somatosensory modalities of touch, itch, and pain. Recent studies have revealed an underlying modular architecture in which nociceptive, pruritic, and innocuous stimuli are processed by distinct molecularly defined interneuron cell types. These include excitatory populations that transmit information about both innocuous and painful touch and inhibitory populations that serve as a gate to prevent innocuous stimuli from activating the nociceptive and pruritic transmission pathways. By dissecting the cellular composition of dorsal-horn networks, studies are therefore beginning to elucidate the intricate computational logic of somatosensory transformation in health and disease. Expected final online publication date for the Annual Review of Physiology Volume 80 is February 10, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

A current and clear review on dorsal horn circuits

Topic		Replies	Views
Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch Journal Club	0	538	August 7, 2019
Neuronal diversity in the somatosensory system: bridging the gap between cell type and function Journal Club	0	534	August 7, 2019
Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia Journal Club spinal_circuit	1	596	August 7, 2019
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch Journal Club	0	714	November 17, 2017
Touch and tactile neuropathic pain sensitivity are set by corticospinal projections Journal Club	0	567	September 16, 2018

Spinal Circuits for Touch, Pain, and Itch

Related topics