Looking for some input here. I want to try CPA, but it seems not so easy to create any kind of consistent results. Maybe thermal gradient? Formalin (licking)? Hot plate (jumping/licking)? Any suggestions for mechanical assays? Any ideas would be great!

@ShanTan See this thread: [image] Has anyone tried conditioned place aversion (CPA) with pain? Animal Behavior and Models I saw this CPA assay in a paper from Cheng et al. (2017) https://www.nature.com/articles/nn.4549 [07 PM] This looks laborious but useful. To meas…

We are now trying to set up the CPA in the model of Paclitaxel and SNI. I took a look in the Cheng paper. We are trying to avoid white and black boxes. We are using one white and one striped (black and white) chamber or one striped vertical and one horizontal. You should remember mice love dark plac…

Thanks Thiago! I tried the Cheng setup. I had a special chamber made. Truth is, the mice didn’t even like the dark very much more. It was still 50/50! I used dark red plexiglass so that I could still see inside but to the mice it should be dark. Light can still come up from the floor, but not so muc…

this is a subsection piece from one of our unpublished (hopefully soon) reviews, that very briefly mentions some behaviors we like: " Measuring pain affect in preclinical models by linking neural activities to volitional behaviors The brain is all about movement. Undeniably, brains are not functio…

Best "supraspinal" nociceptive assays?

Experimental Techniques Animal Behavior and Models

achamess September 10, 2019, 12:23am 2

@ShanTan
See this thread:

Topic		Replies	Views
Real-time place preference/aversion apparatus: a proposal/idea Animal Behavior and Models	10	7845	September 20, 2016
Has anyone tried conditioned place aversion (CPA) with pain? Animal Behavior and Models	10	3713	April 16, 2019
Conditioned Place Aversion (CPA) assays in Mice.. Thoughts? Animal Behavior and Models	6	3230	July 21, 2016
Rodent behavioral assays for cold sensation/pain Animal Behavior and Models	7	1202	September 23, 2021
What's new in nociceptive behavior assays? Animal Behavior and Models	4	879	August 5, 2019

Best "supraspinal" nociceptive assays?

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