So I want to assay the aversive effect of an intervention on mice, and I’m thinking that a CPA assay may be the way to go. Much of the operant conditioning assay work I’ve seen is done in rats, but some papers are coming out using mice. I’ve listed some below.
If you’ve used CPA before in mice, and you’d be willing to share your in-house protocol or any tips, I’d very much appreciate it. @ram_kandasamy and @LegakisL: do you guys have any experience with mice using CPA?
References for CPA assay in mice
- The Conditioned Place Preference Test for Assessing Welfare Consequences and Potential Refinements in a Mouse Bladder Cancer Model
- Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice.
- The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor
- Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma