I have the same impression about the models. SNI produces robust mechanical allodynia and significative cold allodynia in acetone test. This is a problem when you are interesting in endogenous inhibitory mechanisms. To overcome, we normally use the von Frey filament in frequency model besides the up and down. So we can observe enhanced hypersensitivity in some cases (eg KO for some antinociceptive gene). In rare cases autotomy.
Regarding paclitaxel, we performed a dose response curve (2, 4 and 8 mg/kg/day four injections). We found that only the dose of 8 mg/kg produced a consistent mechanical and cold allodynia. On the other hand, this dose was the only one that produced hypoalgesia in Hargreaves test . We also observed a robust sensory neuronal loss/retraction in the paw skin (We used Nav1.8Cre Tdtomato animals). These phenotypes are long-lasting (up to 35 days).
Noteworthy, all these data were in B6 mice.
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